When I got my first 80lb compound a fews back, (I brought it back to about 65lb) I found I couldn't pull it back with my right, and so used my left. I know your circumstances are differerent but after a bit of a workout and building up my arms a bit, I found the change a little troubling at first. because I was used to aiming while holding with my left, my shots were always off target by a fair margin.
Once I got used to the change I found it was quite easy to aim, and I returned to my normal accuracy within a few shots.
Again, as your circumstances are different it may take a little longer to make the switch but I found that over all it was very easy to change.